|LETTER TO THE EDITOR
|Year : 2013 | Volume
| Issue : 2 | Page : 62-63
Comparison between responses following use of fentanyl on heart rate and mean arterial pressure during endotracheal intubation and laryngeal mask airway insertion
Satrajit Dawn1, Arunima Chaudhuri2, Debashis Saha3, Sumanta Ghosh Maulik4
1 Department of Anaesthesia, National Medical College, Kolkata, West Bengal, India
2 Departments of Physiology, Burdwan Medical College and Hospital, Burdwan, West Bengal, India
3 Department of Anaesthesia, Murshidabad Medical College, Berhampore, West Bengal, India
4 Departments of Anaesthesiology, Burdwan Medical College and Hospital, Burdwan, West Bengal, India
|Date of Submission||24-Jul-2013|
|Date of Acceptance||29-Oct-2014|
|Date of Web Publication||11-Jul-2014|
Departments of Physiology, Burdwan Medical College and Hospital, Burdwan, West Bengal
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Dawn S, Chaudhuri A, Saha D, Maulik SG. Comparison between responses following use of fentanyl on heart rate and mean arterial pressure during endotracheal intubation and laryngeal mask airway insertion. Int J Stud Res 2013;3:62-3
|How to cite this URL:|
Dawn S, Chaudhuri A, Saha D, Maulik SG. Comparison between responses following use of fentanyl on heart rate and mean arterial pressure during endotracheal intubation and laryngeal mask airway insertion. Int J Stud Res [serial online] 2013 [cited 2020 Jul 11];3:62-3. Available from: http://www.ijsronline.net/text.asp?2013/3/2/62/136506
Hemodynamic responses to intubation and laryngoscopy may have deleterious effects ,, and measures to minimize them are necessary. The present study was conducted to observe the heart rate and mean arterial pressure following laryngeal mask airway (LMA) insertion and endotracheal intubation after administration of fentanyl.
A total of 68 patients in the age group between 20 and 45 years, of either sex, belonging to American Society of Anesthesiologists physical Status I or II and Mallampati Grade I  , scheduled for various elective surgical procedures with likely duration of not more than 30-45 min, were selected for this pilot project. The study was carried out in a time span of 3 months and all patients who came to us and met the inclusion criteria were included for the study. Patients with a history of cardiovascular, gastroesophageal reflux and respiratory diseases, those on cardioactive drugs, diabetics and pregnant women were excluded. Institutional ethical clearance was taken before the commencement of the study and informed consent of the subjects were obtained.
Heart rate, blood pressure, electrocardiogram and oxygen saturation were serially recorded. The patients were divided randomly into two groups, comprising of 34 patients in each group (Group A and B). After securing intravenous access, the patients in both groups were given injection fentanyl 1-2 μg/kg intravenously, 4-5 min before induction of anesthesia. After preoxygenation, patients received injection thiopentone sodium (2.5%) intravenously at around 3-4 mg/kg. Neuromuscular blockade was achieved by injection atracurium besylate 0.5 mg/kg. Patients were then ventilated with 100% oxygen for about 4 min. Subsequently, tracheal intubation was done in patients of Group A, whereas LMA was inserted blindly in patients of Group B. Statistical analysis was performed using paired t-test (for pre-operative values and the values at different time intervals) and unpaired t-test (for different values between Group A and B).
In Group A and B, there was a significant rise in heart rate immediately before and 1 min after airway instrumentation [Table 1] and [Table 2], while in Group B this rise, significantly lasted until 3 min. Heart rate in Group A was significantly lower than B at 3 and 5 min post airway instrumentation. There was a significant rise in mean arterial pressure (MAP) in both groups following airway instrumentation at 1 min. In Group A, MAP was significantly higher at 1 min following airway instrumentation when compared to Group B [Table 2].
|Table 1: Heart rates (beats/min) in group A and B and its comparison at different points of time |
Click here to view
|Table 2: MAP (mmHg) in group A and B and its comparisons at different points of time |
Click here to view
The use of a LMA was associated with a truncated response of hemodynamic parameters when compared with endotracheal intubation in the present study. This is similar to the findings of Bukhari et. al.  and Joad et. al.  There was a significant difference in mean arterial blood pressure at 1 min post airway instrumentation among the two groups. The shorter duration of the rise in blood pressure in both groups when compared to previous studies , could be due to the use of fentanyl in this study. A similar result was also noticed with the use of fentanyl by Zhang et. al. in 2009  . Jamil et. al. in 2009  suggested LMA as a suitable alternative to endotracheal intubation for positive pressure ventilation in children.
| References|| |
|1.||Bukhari SA, Naqash I, Zargar J, Nengroo S, Mir AW. Pressor responses and intraocular pressure changes following insertion of laryngeal mask airway: comparison with tracheal tube insertion. Indian J Anaesth 2003;47(6):473-5. |
|2.||Joad AS, Mulay MA. Ocular hypertensive and pressor response on insertion and removal of LMA. J Anaesth Clin Pharmacol 2005;21(3):265-70. |
|3.||Zhang GH, Sun L. Peri-intubation hemodynamic changes during low dose fentanyl, remifentanil and sufentanil combined with etomidate for anesthetic induction. Chin Med J (Engl) 2009;122(19):2330-4. |
|4.||Jamil SN, Alam M, Usmani H, Khan M M. A Study of the Use of Laryngeal Mask Airway (LMA) in Children and its Comparison with Endotracheal Intubation. Indian J Anaesth 2009;53(2):174-8. |
[Table 1], [Table 2]