Diffuse large B-cell lymphoma is a Non-Hodgkin's lymphoma (NHL), which has diverse manifestations. Extra-nodal NHL is extremely rare entity. Diagnosis, staging and treatment plan of the patient depends on the clinical findings and radiographic investigations. Positron emission tomography computed tomography (PET CT) scan helps in localization of the lesion and also for posttreatment restaging. Here we are presenting a case report of a 21-year-old patient with diffuse large B-cell lymphoma. This case report highlights the importance of imaging for localization of the lesion and posttreatment evaluation of the lesion.

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Central Giant Cell Granuloma (CGCG) was differentiated from Giant Cell Tumor of bone by Jaffe in 1953. Various authors have advocated this intraosseous lesion as a reactive lesion or developmental anomaly or a benign neoplasm. Actual etiology is not comprehensible till date and it has also been hypothesized to have a genetic etiology. Lesions are most commonly found in mandible but frequently crossing the midline. However, variable clinical features and radiological changes have been demonstrated by giant cell lesions of the jaws. In this case report, a young female patient reported with the chief complaint of swelling in right mandibular posterior tooth region since 2 wks after dental extraction from the same region. The patient underwent the treatment as surgical curettage followed by removal of the lesion and subsequent histopathological examination which confirmed the diagnosis of CGCG. There was no recurrence reported in 10 months of follow up.

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Introduction: Rational use of drugs is mandatory for improving the quality of life, optimal utilization of our meagre financial resources, and better community healthcare fulfilling the "rule of right and need, efficacy, suitability, safety, and affordability criteria." Despite this many irrational fixed dose combinations (FDCs) are continuously springing up in the Indian pharmaceutical market. Hence, it becomes crucial to evaluate the prescribing patterns of FDCs - the current trends and the loopholes. Methodology: This study was carried out in the outpatient department of medicine at Mahatma Gandhi Medical College and Hospital, Jaipur. Total 500 prescriptions were collected for the duration of 6 months, starting from February 2014 and assessed. The data was analyzed using Microsoft Office Excel^; version 2007. Results: The data analysis reflected that 60% of prescriptions analyzed contained FDCs; revealing that significantly high number of patients received FDCs. The total number of FDCs in a prescription was also greater (mean = 1.82). Out of 60 FDCs prescribed only three of them were enlisted in the Essential Medicine List of World Health Organization and Government of India. Conclusion: The increased trend in using irrational FDC warrants a drug regulatory body in every hospital to ameliorate the free flow of irrational FDCs. Awareness programs focusing on deleterious consequences related to irrational use of medicines should be made.

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